Avian antimicrobial peptides in hen reproductive tract and egg

نویسندگان

  • V. Hervé-Grépinet
  • S. Réhault-Godbert
  • J. Gautron
  • M. Hincke
  • Y. Mine
  • Y. Nys
چکیده

Recently, many avian antimicrobial peptides have been predicted by bioinformatics and identified by proteomics. These compounds are generally small cationic molecules that possess activities against protozoans, fungi and viruses, as well as gram-positive and gram-negative bacteria. They are components of innate immunity and are capable of evading pathogen resistance mechanisms. Hens export protective molecules into the egg in order to anticipate defence of the embryo. In this review, we focus on avian antimicrobial peptides (AMPs) derived from the oviduct and found within the egg compartments. Indeed, the egg whose formation takes place in the oviduct is not only a source of nutrients for the embryonic development of the bird; it is also a reserve of protective molecules against physical and microbial aggression. Furthermore, enzymatic hydrolysis of egg proteins can release additional peptides that possess antimicrobial activities. Here, we describe the biochemical characteristics and the mechanisms of action of avian AMP families existing in the oviduct and in the egg. Moreover, we introduce novel applications of these peptides: they are potential candidates for marker assisted selection of increased antimicrobial egg defences and for development as neutraceuticals of major interest for human health or/and nutrition.

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تاریخ انتشار 2009